Fluoxetine

Product Name: Fluoxetine

Synonyms: (+/-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;METHYL-[3-PHENYL-3-(4-TRIFLUOROMETHYLPHENOXY)PROPYL]AMINE;AURORA KA-7692;FLUOXETINE;(+-)-benzenepropanamin;(+)or(-)-n-methyl-3-phenyl-3-(alpha,alpha,alpha-trifluoro-p-tolyl)oxy)prop;(+)or(-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine;dl-3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine

CAS: 54910-89-3

MF: C17H18F3NO

MW: 309.33

EINECS: 611-209-7

Product Categories: CEFTIN;API

In fluoxetine (Prozac), protonated in vivo, the protonatedamino group can H-bond to the ether oxygen electrons, whichcan generate the β-arylamino–like group, with the other arylserving as the characteristic “extra” aryl. The S-isomer ismuch more selective for SERT than for NET. The majormetabolite is the N-demethyl compound, which is as potent asthe parent and more selective (SERT versus NET).

Therapy for 2 or more weeks is required for the antidepressanteffect. Somatodendritic 5-HT1A autoreceptor desensitizationwith chronic exposure to high levels of 5-HT isthe accepted explanation for the delayed effect for this andother serotonin reuptake inhibitors.