Dihexa

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1.What is Dihexa ?

Dihexa(PNB-0408), an oligopeptides reagent, is an orally active, blood-brain barrier permeable angiotensin IV analogue. Dihexa binds hepatocyte grow-th factor (H-G-F) with high affinity, with a Kd value of 65pM, and enhances its activity against the receptor c-Met. Dihexa has shown excellent antipsychotic activity as well as improved cognitive function in animal models. Dihexa has the potential to study Alzheimer's disease.

2.What is it used for?

N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.

Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte grow-th factor (H-G-F) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer's disease.

Dihexa is a peptide variant derived from angiotensin IV which has been found to potently improve cognitive function in animal models of disease such as Alzheimer's. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease.

3.What are the specifications of this product?