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ChemicalBook Product Catalog Biochemical Engineering Plant extracts Digitonin

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Digitonin NEW

$ 29.00 /25mg

Min. Order
Purity50%
Cas No11024-24-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Digitonin
CAS No	11024-24-1
EC-No
Min. Order
Purity	50%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Digitonin
Description	Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of cell membranes in a wide range of cells.
In vitro	METHODS: Rat adrenal pheochromocytoma cells PC-12 were treated with Digitonin (10 μg/mL) for 10 min to increase cell permeability. RESULTS: After permeabilization with Digitonin, PC12 cells could be stimulated to release norepinephrine by micromolar concentrations of free Ca2+. [1] METHODS: Human glioblastoma cells U87 were treated with Digitonin (1-5 μg/mL) for 20 min, and cell viability was measured by MTT after overnight cell incubation. RESULTS: 1 μg/mL Digitonin treatment resulted in a slight increase in cell viability, 3 μg/mL Digitonin reduced the growth-promoting effect, and the cell viability was similar to that of the control, and 5 μg/mL Digitonin inhibited the cell viability, which indicated a significant toxicity to the cells. [2] METHODS: Immortalized human T-lymphocytes Jurkat were treated with Digitonin (1-4 μg/mL) for 20 min and cell viability was measured by Resazurin assay. RESULTS: Digitonin treatment resulted in a significant decrease in metabolic activity and this inhibition was concentration-dependent. [2]
In vivo	METHODS: To determine whether Digitonin enhances the efficacy of CBDCA in vivo, Digitonin (0.2 mL 400 μM) was hepatic arterially infused into LH rats bearing hepatocellular carcinoma tumors, followed by injection of CBDCA 10 min later. RESULTS: Digitonin pretreatment increased the tumor uptake of CBDCA and enhanced the cytotoxic effect of CBDCA. [3]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 27.5 mg/mL (22.37 mM)
Keywords	permeability \| Inhibitor \| inhibit \| mild \| cell \| cholesterol \| detergent \| molecules \| Digitonin
Related Compound Libraries	Anti-Tumor Natural Product Library \| Bioactive Compound Library \| Selected Plant-Sourced Compound Library \| Drug Repurposing Compound Library \| Natural Product Library \| Anti-Cancer Approved Drug Library \| Natural Product Library for HTS \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library

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