1. Materials information
Names
| Name | digitonin |
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| Synonym | More Synonyms |
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Digitonin Biological Activity
| Description | Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. |
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| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Saccharides and Glycosides |
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| In Vitro | Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1]. |
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| In Vivo | In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg[1]. |
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| References | [1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Melting Point | 230-240ºC |
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| Molecular Formula | C56H92O29 |
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| Molecular Weight | 1229.312 |
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| Exact Mass | 1228.572388 |
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| PSA | 454.67000 |
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| LogP | -0.62 |
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| Index of Refraction | 1.660 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods under 50kg
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Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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