| Name | Clorsulon |
| Description | Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep. |
| In vitro | In sheep and calves, a single administration of Clorsulon (15 mg/kg) effectively induces damage to the cortical and intestinal tissues of the liver flukes, thereby expelling immature liver flukes from the host organism. |
| In vivo | Clorsulon is a competitive inhibitor (Ki=0.29 mM) of both 3-phosphoglycerate and ATP, capable of suppressing glucose utilization and the formation of acetate and propionate. |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 7 mg/mL (18.39 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.25 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 71 mg/mL (186.52 mM), Sonication is recommended.
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| Keywords | Parasite | MK-401 | MK 401 | L-631529 | L 631529 | Inhibitor | inhibit | glucose utilization | gigantica | Flukicidal | Fasciola | Clorsulon | ATP | Antibiotic | 3-phosphoglycorate |
| Inhibitors Related | Neomycin sulfate | Kaempferol | Ampicillin sodium | Kojic acid | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Hydroxychloroquine | Metronidazole | Doxycycline | EDTA copper(II) disodium salt |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Toxic Compound Library | Antibiotics Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Compound Library |
United States
