Clorsulon is a sulfonamide antiparasitic agent.
1 It induces swelling and blebbing and reduces motility of
F. hepatica mature flukes when used at a concentration of 10 μg/ml.
In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of
F. hepatica infection.
2 It completely eradicates naturally acquired
F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg.
3 Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.