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ChemicalBook Product Catalog API Antibiotics Macrolides Clarithromycin

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Clarithromycin NEW

$50.00 100mg

$57.00 200mg

$74.00 500mg

Min. Order
Purity99.89%
Cas No81103-11-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Clarithromycin
CAS No	81103-11-9
EC-No
Min. Order
Purity	99.89%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Clarithromycin
Description	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
In vitro	Clarithromycin suppresses this production in a dose-dependent manner in both monocytes and THP-1 cells. Clarithromycin regulates three other promoters that have either the NF-kappa B or the AP-1 binding sequences: two synthetic (pAP-1-Luc and pNF-kappa B-Luc) and one naturally occurring (ELAM-Luc). [1] Clarithromycin suppresses NF-kappaB activation induced by TNF-alpha in U-937 and Jurkat cells in a concentration-related manner. Clarithromycin inhibits NF-kappaB activation induced by TNF-alpha in U-937, Jurkat, and A549 cells and PBMC and by SEA in PBMC. Clarithromycin prevents NF-kappaB-dependent reporter gene expression in U-937 cells. [2] Clarithromycin results in a significant suppression of production of each cytokine in 71% and a significant increase in 29% of the human monocytes. [3] Clarithromycin inhibits tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. Clarithromycin represses AP-1 binding in TNF-alpha-treated BET-1A cells. Clarithromycin represses IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. [4] Clarithromycin suppresses IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Clarithromycin suppresses intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta. Clarithromycin reduces DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively. [5]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (66.85 mM)
Keywords	CYPs \| A56268 \| CYP3A4 \| Clarithromycin \| HERG \| Inhibitor \| potassium \| autophagic \| current \| Antimicrobial \| flux \| A 56268 \| inhibit \| Cytochrome P450 \| Bacterial \| Autophagy \| Antibiotic
Inhibitors Related	Neomycin sulfate \| Sulfamethoxazole sodium \| Hydroxychloroquine \| Guanidine hydrochloride \| Doxycycline \| Dimethyl sulfoxide
Related Compound Libraries	Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Cancer Approved Drug Library \| FDA-Approved Drug Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library

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Company Profile Introduction

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