| 名称 | Artesunate |
| 描述 | Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines. |
| 细胞实验 | Growth inhibition assay: The SKM-1 cells (1×105/mL) are firstly seeded in 96-well plates. Artesunate is diluted in 0.1% dimethyl sulfoxide (DMSO) producing 0, 12.5, 25, 50µg/mL concentrations and added to the SKM-1 cells with 100 µl per well. A negative control is treated with 0.1% DMSO. At 0, 24, 48, and 72 hours, same amount of MTT solution is added into each well and cultured for extra 4 hours. MTT treated cells are fixed with 150 µL DMSO for 30 min at room temperature and then determined with Evolution 201 and 220 UV-Vis spectrophotometer system at 540 nm. (Only for Reference) |
| 体外活性 | ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion [2]. The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin[3]. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells[1]. |
| 体内活性 | Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice[5]. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen[6]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 9 mg/mL (23.4 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (143.07 mM)
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| 关键字 | Virus Protease | inhibit | WR256283 | WR 256283 | Parasite | Inhibitor | Ferroptosis | Artesunate | STAT |
| 相关产品 | Phenytoin sodium | Acetylcysteine | Kaempferol | Hydroxychloroquine | Metronidazole | Sorafenib | Doxycycline | Curcumin | L-Cystine | Benzyl benzoate |
| 相关库 | 抗寄生虫库 | 经典已知活性库 | EMA 上市药物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 天然产物库 | 中药抗炎分子库 | 已知活性化合物库 | 抗病毒中药单体化合物库 | 抗癌药物库 |
United States
