Argipressine NEW

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Min. Order1KG
Purity98%~99%
Cas No113-79-1
Supply Ability20 T each week
Update time2023-08-16

Shandong Huisheng Import & Export Co., Ltd.

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China

Chemical Properties

Product Name	Argipressine
CAS No	113-79-1
EC-No	204-035-4
Min. Order	1KG
Purity	98%~99%
Supply Ability	20 T each week
Release date	2023/08/16

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Product Name:	Argipressine
Synonyms:	[ARG8]-VASOPRESSIN (HUMAN, BOVINE, OVINE, RAT, MOUSE);[ARG8]-VASOPRESSIN;[ARG8]-VASOPRESSIN (AVP);ANTIDIURETIC HORMONE;AVP;BETA-HYPOPHAMINE;β-Hypophamine;(ARG8)-VASOPRESSIN GRADE VI SOLUTION*APP ROX. 100 I.
CAS:	113-79-1
MF:	C46H65N15O12S2
MW:	1084.24
EINECS:	204-035-4
Product Categories:	Amino Acid Derivatives;Vasopressin and Oxytocin receptor;Peptide Receptors;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Peptide;113-79-1
Mol File:	113-79-1.mol

Argipressine Chemical Properties

density	1.59±0.1 g/cm3(Predicted)
Fp	113℃
storage temp.	2-8°C
pka	9.90±0.15(Predicted)
PH	~3.5
Water Solubility	Water : ≥ 360 mg/mL (332.03 mM)

Safety Information

Hazard Codes	Xn
Risk Statements	20
Safety Statements	36
WGK Germany	3
HS Code	2937190000
Toxicity	TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000

MSDS Information

Provider	Language
SigmaAldrich	English

Argipressine Usage And Synthesis

Uses	Hormone (antidiuretic).
Uses	[Arg⁸]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.
Definition	ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
Indications	ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V₂ that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V₂ receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V₃ (or V_1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.
Brand name	Pitressin (Parke-Davis).
General Description	Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously.
Hazard	A poison.
Biochem/physiol Actions	[Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.
Mechanism of action	ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.
Clinical Use	Because it is stable, desmopressin is preferred for treatments especially if pressor effects are not desired. The primary indication for therapy is central diabetes insipidus, a disorder that results when ADH secretion is reduced and that is characterized by polydipsia, polyuria, and dehydration. Desmopressin is also used to reduce primary nocturnal enuresis, or bedwetting, in children. It is useful in people with mild hemophilia A or with some types of von Willebrand’s disease, in which von Willebrand’s factor is present at low levels. In these cases, desmopressin is given when excessive bleeding occurs or before surgery to help reduce bleeding indirectly by increasing the amounts of coagulation factors. A possible adverse effect of desmopressin is water intoxication if too much is taken. ADH antagonists, including nonpeptide analogues that may be taken orally, have been developed with specificity for each of the receptor types. In the future, those that block V1 receptors may be useful in treating hypertension, and those that block V2 receptors may be useful in any condition of excessive water retention or hyponatremia, for which so far there is no satisfactory therapeutic treatment.
Safety Profile	A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.
storage	Store at -20°C