Diabetes insipidus Drugs

Diabetes insipidus is a kind of disease which results in the reduction of antidiuretic hormone secretion and release. The main symptoms of diabetes insipidus are polyuria, polydipsia and dehydration. And Drug therapy of diabetes insipidus refers to the drugs which could help improve those symptoms.
These drugs could be divided into two categories:
one is posterior pituitary preparation which contains antidiuretic hormone (or vasopressin), such as posterior lobe inhaler and injections, as well as the recent manmade vasopressin like Lysine vasopressin. They all belong to replacement therapy drugs, which could easily destroyed by trypsin. So these drugs cannot be administered orally but mucosal or parenteral administrations are suitable.

Another type of drugs for oral administration, such as hydrochlorothiazide, etc., is only efficient for the patients who have a mild diabetes insipidus. However, it has seldom effect on the patients who has suffered from a serious diabetes insipidus. For the function and usage, see the introduction of Diuretics.

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