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ChemicalBook Product Catalog Adenosine Dialdehyde (ADOX)

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Adenosine Dialdehyde (ADOX) NEW

$50.00 5mg

$64.00 10mg

$95.00 25mg

Min. Order
Purity95.00%
Cas No34240-05-6
Supply Ability10g
Update time2025-11-04

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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Chemical Properties

Product Name	Adenosine Dialdehyde (ADOX)
CAS No	34240-05-6
EC-No
Min. Order
Purity	95.00%
Supply Ability	10g
Release date	2025/11/04

Product Introduction

Bioactivity

Name	Adenosine Dialdehyde (ADOX)
Description	Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
In vitro	Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1].
In vivo	Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 45 mg/mL (169.66 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.54 mM), Sonication is recommended.
Keywords	S-adenosylhomocysteine hydrolase \| ADOX \| Adenosine Dialdehyde
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Adenosine \| Floxuridine \| Uridine \| Capecitabine \| 5-BrdU \| Cytidine \| Adenosine 5'-monophosphate disodium salt \| Cytarabine \| Ganciclovir \| 6-Mercaptopurine
Related Compound Libraries	Bioactive Compound Library \| Inhibitor Library \| Bioactive Compounds Library Max \| Covalent Inhibitor Library \| Anti-Cancer Compound Library \| Anti-Cancer Active Compound Library \| Nucleotide Compound Library

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