| 名称 | ABT-724 |
| 描述 | ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM) |
| 动物实验 | ABT-724 (maleate salt) was freshly prepared and administered to rats via s.c. injection into the back neck area (1 ml/kg injection volume). For intracerebroventricular (ICV) or intrathecal administrations, rats were allowed at least 1 week of recovery from surgery before behavioral testing. The compounds of interest were infused ICV (left lateral ventricle) in a 5-μl volume or 10 μl intrathecally. After the experiment was completed, infusion of 0.5% fast-green dye in saline solution and subsequent dissection were carried out to confirm the diffusion of the injection solution[1]. |
| 体外活性 | ABT-724 is a selective dopamine D(4) receptor agonist that activates human dopamine D(4) receptors with an EC(50) of 12.4 nM and 61% efficacy, with no effect on dopamine D(1), D(2), D(3), or D(5) receptors[1]. |
| 体内活性 | ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an effect that is blocked by haloperidol and clozapine but not by domperidone.?A proerectile effect is observed after intracerebroventricular but not intrathecal administration, suggesting a supraspinal site of action.?s.c. injections of ABT-724 increase intracavernosal pressure in awake freely moving rats.?In the presence of sildenafil, a potentiation of the proerectile effect of ABT-724 is observed in conscious rats.?The ability of ABT-724 to facilitate penile erection together with the favorable side-effect profile indicates that ABT-724 could be useful for the treatment of erectile dysfunction[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mg/mL (34.09 mM)
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| 关键字 | Inhibitor | Dopamine Receptor | penile | erection | D4-receptor | Dopamine | inhibit | ABT-724 | ABT 724 | ABT724 | potentiation,side-effect |
| 相关产品 | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
| 相关库 | 神经退行性疾病化合物库 | 经典已知活性库 | 抗抑郁症化合物库 | 膜蛋白靶向化合物库 | ReFRAME 相关化合物库 | 抗帕金森病化合物库 | 神经递质受体化合物库 | NO PAINS 化合物库 | 已知活性化合物库 | GPCR靶点分子库 |
United States
