Name | ABT 724 trihydrochloride |
Description | ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies. |
In vitro | A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6[1]. |
In vivo | In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 100 mg/mL (248.29 mM) DMSO : 60 mg/mL (148.98 mM), Sonication is recommended.
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Keywords | ABT-724 Trihydrochloride | Inhibitor | ABT724 Trihydrochloride | Dopamine Receptor | penile | ABT 724 Trihydrochloride | inhibit | potentiation,side-effect | ABT-724 trihydrochloride | ABT-724 | Dopamine | D4-receptor | ABT 724 trihydrochloride | ABT724 | erection | ABT 724 |
Inhibitors Related | Olanzapine | CLOZAPINE N-OXIDE | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride | Fluphenazine dihydrochloride |
Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |