| Name | Zonisamide |
| Description | Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate. |
| In vitro | Zonisamide inhibits monoamine oxidase B activity in vitro with an IC50 of 25 μM. |
| In vivo | Zonisamide inhibits monoamine oxidase B activity in vitro with an IC50 of 25 μM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (1177.97 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.42 mM), Sonication is recommended.
|
| Keywords | Zonisamide | SodiumChannel | Sodium Channel | SH-SY5Y | seizure | parkinson's disease | NRCMs | Inhibitor | inhibit | epilepsy | CI-912 | CI912 | cardiac hypertrophy | cardiac fibroblasts | CarbonicAnhydrase | Carbonic Anhydrase | Carbonate dehydratase | CalciumChannel | Calcium Channel | Apoptosis | AD-810 | AD810 |
| Inhibitors Related | Stavudine | Aceglutamide | 2,4,6-Tri-tert-butylphenol | Tamoxifen | Urea | Cysteamine hydrochloride | Sodium Dihydrogen Phosphate | Metronidazole | Citric Acid Triammonium | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
