| Name | Norepinephrine |
| Description | Norepinephrine is an alkaloid neurotransmitter and an effective adrenergic receptor (AR) agonist that activates α1, α2, and β1 receptors. It is commonly used as a vasoactive agent for the treatment of shock and can also be used to induce cardiomyopathy models. |
| In vitro | METHODS: Adult hippocampal cells were treated with Norepinephrine (0.1-10 µM) for 10-13 days and the number of neurospheres was determined using classical neurosphere assay.
RESULTS: A significant increase in the number of neurospheres was obtained at 100 nm and in the presence of 1 µM Norepinephrine, and a twofold increase in the number of neurospheres was observed in the presence of 10 µM Norepinephrine. [1]
METHODS: Human pancreatic cancer cells BxPC-3 and Panc-1 were treated with Norepinephrine (10 µM) for 12-48 h. Cell viability was assayed by MTT Assay.
RESULTS: Norepinephrine treatment alone significantly enhanced the viability of PDAC cells. [2] |
| In vivo | METHODS: To test in vivo activity, Norepinephrine (0.2-2 mg/kga) was administered intraperitoneally to C57BL6/J mice fed a high-fat diet once daily for two weeks.
RESULTS: A subset of Norepinephrine-treated mice developed unexpected adverse events, including bladder dilatation and decreased renal perfusion due to renal discoloration. [3] |
| Storage | keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 0.1M HCl : 10 mg/mL (59.11 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 8.46 mg/mL (50.01 mM), Sonication and heating are recommended.
10% DMSO+90% Saline : 0.1 mg/mL (0.59 mM), Solution.
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| Keywords | β1-adrenoceptor | α2A-adrenoceptor | α1-adrenoceptor | Norepinephrine | MMP-9 | MMP-2 | Levarterenol | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Beta Receptor | Autophagy | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | D-(+)-Trehalose dihydrate | Formamide | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Alkaloid Natural Product Library | Miao medicine Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library |
United States
