Product Name: Nimesulide
Synonyms: Nimesulide,N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Lizepat;4-Nitro-2-(phenoxy-d5) MethanesulfonaMide-d5;4'-Nitro-2'-(phenoxy-d5)Methanesulfonanilide;Aulin-d5;Flogovital-d5;nimed;4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE
CAS: 51803-78-2
MF: C13H12N2O5S
MW: 308.31
EINECS: 257-431-4
Product Categories: Aromatics;Isotope Labelled Compounds;-;Sulfur & Selenium Compounds;Other APIs;Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 51803-78-2.mol
Nimesulide Structure
Nimesulide Chemical Properties
Melting point 140-146°C
Boiling point 442.0±55.0 °C(Predicted)
density 1.451±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
pka pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
form neat
Water Solubility Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax 391nm(H2O)(lit.)
Merck 14,6548
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference 51803-78-2(CAS DataBase Reference)
EPA Substance Registry System Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 36-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS PB0970000
HazardClass 6.1
PackingGroup III
Toxicity LD50 orally in rats: 324 mg/kg (Swingle, Moore)
China
