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Nimesulide

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Nimesulide Basic information
Nimesulide Chemical Properties
  • Melting point:140-146°C
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
  • form neat
  • pkapKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
  • Water Solubility Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
  • λmax391nm(H2O)(lit.)
  • Merck 14,6548
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • InChIKeyHYWYRSMBCFDLJT-UHFFFAOYSA-N
  • CAS DataBase Reference51803-78-2(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/37/38
  • Safety Statements 36-26
  • RIDADR UN 2811 6.1/PG 3
  • WGK Germany 3
  • RTECS PB0970000
  • HazardClass 6.1
  • PackingGroup III
  • ToxicityLD50 orally in rats: 324 mg/kg (Swingle, Moore)
MSDS
Nimesulide Usage And Synthesis
  • DescriptionNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
  • Chemical PropertiesYellow Needle-Like Crystals
  • OriginatorRiker (USA)
  • UsesAntiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production
  • UsesLabelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.
  • UsesAntiinflammatory;'Cyclooxygenase 2 inhibitor
  • UsesFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
  • UsesLabelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th
  • UsesNimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]
  • brand nameNimulid.
  • Biological ActivitySelective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.牋.
  • Clinical UseNimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.
  • Referenceshttps://en.wikipedia.org/wiki/Nimesulide
    https://www.drugbank.ca/drugs/DB04743
Nimesulide Preparation Products And Raw materials
Nimesulide(51803-78-2)Related Product Information
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