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Amiloride hydrochloride
$ 1.00
/1KG
- Min. Order1KG
- Purity98%
- Cas No2016-88-8
- Supply Ability200kg
- Update time2019-09-02
career henan chemical co
7YR
China
China
Since2014-12-17
Address No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
Chemical Properties
| Product Name | Amiloride hydrochloride |
| CAS No | 2016-88-8 |
| EC-No | |
| Min. Order | 1KG |
| Purity | 98% |
| Supply Ability | 200kg |
| Release date | 2019/09/02 |
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Product Name:
Amiloride hydrochloride
Synonyms:
amiloridechloride;amiprazidine;n-amidino-3,5-diamino-6-chloro-pyrazinecarboxamidmonohydrochloride;3,5-DIAMINO-N-(AMINOMETHYL)-6-CHLOROPYRAZINE CARBOXAMIDE HYDROCHLORIDE;HCL AMILORIDE HCL;N-amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride;Amipramidin hydrochloride;Amipramizide hydrochloride
CAS:
2016-88-8
MF:
C6H8ClN7O.ClH
MW:
266.09
EINECS:
217-958-2
Product Categories:
Active Pharmaceutical Ingredients;Ion transporter and other ion channel;Ion Channels;Amines;Bases & Related Reagents;Heterocycles;-;MIDAMOR;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
Mol File:
2016-88-8.mol
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Amiloride hydrochloride Chemical Properties
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Melting point
293-294°C
storage temp.
Store at RT
solubility
H2O: 50 mg/mL, clear, yellow-green
form
powder
color
yellow
Water Solubility
<0.1 g/100 mL at 19.5 ºC
CAS DataBase Reference
2016-88-8(CAS DataBase Reference)
EPA Substance Registry System
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)- 6-chloro-, monohydrochloride(2016-88-8)
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Safety Information
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Hazard Codes
T,Xi
Risk Statements
25-36/37/38
Safety Statements
36-45-26
RIDADR
UN 2811 6.1/PG 3
WGK Germany
3
RTECS
UQ2275500
HazardClass
6.1(a)
PackingGroup
II
HS Code
29339980
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MSDS Information
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Amiloride hydrochloride
English
SigmaAldrich
English
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Amiloride hydrochloride Usage And Synthesis
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Chemical Properties
Pale Yellow Solid
Uses
Na+ channel inhibitor, diuretic
Uses
A calcium channel andsodium channel protein inhibitor
Uses
Sodium channel blocker. Diuretic.
Definition
ChEBI: A hydrochloride obtained by combining amiloride with one molar equivalent of hydrochloric acid.
Brand name
Midamor (Merck).
General Description
Crystalline solid or very light yellow powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated amine and amide, acidic salt. In aqueous solution, behaves as a weak acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
SYMPTOMS: Symptoms of exposure to Amiloride hydrochloride include headache, weakness, fatigue, back, chest, neck, shoulder or extremity pain; nausea, anorexia, vomiting, abdominal pain, hyperkalemia, paresthesias, shock, dizziness, coughing, shortness of breath, depression, nervousness, flaccid paralysis of the extremities, bradycardia, flatulence, skin rash, gas pain, constipation and dyspnea.
Fire Hazard
Flash point data for Amiloride hydrochloride are not available; however, Amiloride hydrochloride is probably combustible.
Biological Activity
Na + channel blocker. Defines the I 2A -amiloride sensitive and I 2B -amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels.
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Amiloride hydrochloride Preparation Products And Raw materials
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Raw materials
Ethyl cyanoacetate-->Glyoxal-->Guanidine hydrochlorid
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Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;
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