Doramapimod

Product Name:

Doramapimod

Synonyms:

1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea;DoraMapiMod, BIBR-796;BIBR-796(DoraMapiMod);BIRB 796;BIRB 796 (DoraMapiMod);BIRB 796BS;N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea;DoraMapin BIBR796

CAS:

MF:

C31H37N5O3

MW:

527.66

EINECS:

1308068-626-2

Product Categories:

Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Anti-cancer&immunity;Inhibitors;MAPK

Mol File:

285983-48-4.mol

 

Doramapimod Chemical Properties

 

Safety Information

MSDS Information

 

Doramapimod Usage And Synthesis

Chemical Properties

Pale Beige Solid

Uses

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bo rtezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Definition

ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.