Introduction
1.Name:Chlorphenamine Maleate
2.Cas No:113-92-8
3.MF:C16H19ClN2.C4H4O4
4.MW.:390.87
5.Appearance:white crystalline powder
6.Other Names: Chlorphenamine hydrogen maleate; 1-p-Chlorophenyl-1-(2-pyridyl)-3-dime
Function
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an is chemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
China
