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STAUROSPORINE

$ 1.00 /1KG

Min. Order1KG
Purity98%
Cas No62996-74-1
Supply Ability1T
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	STAUROSPORINE
CAS No	62996-74-1
EC-No
Min. Order	1KG
Purity	98%
Supply Ability	1T
Release date	2019/07/06

CR363

Product Name:	STAUROSPORINE
Synonyms:	STSP;ANTIBIOTIC M 193;ANTIBIOTIC AM-2282;[9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE;2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE;STAUROSPORINE FROM STREPTOMYCES SP.;STAUROSPORINE READY-MADE SOLUTION;STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
CAS:	62996-74-1
MF:	C28H26N4O3
MW:	466.53
EINECS:
Product Categories:	All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Protein Kinase;Signalling;Inhibitor;antibiotic;API
Mol File:	62996-74-1.mol

STAUROSPORINE Chemical Properties

Melting point	270°C
alpha	D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
RTECS	KD5084000
storage temp.	2-8°C
solubility	DMSO: soluble
Water Solubility	Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
InChIKey	HKSZLNNOFSGOKW-WIFUGMKFSA-N

Safety Information

Hazard Codes	Xn,T,Xi
Risk Statements	40-45-36/37/38-46
Safety Statements	36/37-53-36-26-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	2
F	8-10
HazardClass	3
HS Code	29419090

MSDS Information

Provider	Language
SigmaAldrich	English

STAUROSPORINE Usage And Synthesis

Chemical Properties	Light Yellow Solid
Uses	Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Uses	Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Uses	A protein Kinase C inhibitor that induces apoptosis in many cell types
Biological Activity	Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

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