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洛匹那韦（ABT-378）是蛋白酶抑制剂类的抗逆转录病毒药物。它被用作与另一种蛋白酶抑制剂利托那韦的固定剂量组合，用于商品名为的Kaletra（高收入国家）和Aluvia（低收入国家）的HIV感染。它于2000年9月15日首次被FDA批准。

Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra (high-income countries) and Aluvia (low-income countries). It was first approved by the FDA on 15 September 2000.