Neomycin sulfate

CAS:1405-10-3
Name:Neomycin sulfate
Formula:C23H46N6O13.3(H2SO4)
Molecular Weight:908.88
Synonyms:
Fradiomycinum;Neomycin B AND D-Streptamine, Fradiomycin sulfate;
EINECS:215-773-1
Solubility:water: 50 mg/mL
Appearance:White powder
Assay: BP/EP
Package: 25kg/drum
Storage: In an airtight container, protected from light.
Application: A broad-spectrum antibiotic, have a good effect on Staphylococcus aureus, bacillus and Bacillus anth


Description:

Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. The discovery of neomycin dates back to 1949. It was discovered in the lab of Selman Waksman. Neomycin belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.


Uses :

Neomycin is typically used as a topical preparation, such as Neosporin. It can also be given orally, where it is usually combined with other antibiotics. Neomycin is not absorbed from the gastrointestinal tract and has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. By killing bacteria in the intestinal tract, it keeps ammonia levels low and prevents hepatic encephalopathy, especially prior to GI surgery. It has also been used to treat small intestinal bacterial overgrowth. It is not given via injection, as neomycin is extremely nephrotoxic (causes kidney damage), even when compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.