Quick detail
Product Name: |
Estradiol Benzoate |
Synonyms: |
17-beta-Oestradiol 3-benzoate |
CAS RN.: |
50-50-0 |
EINECS: |
200-043-7 |
| Molecular Weight: |
376.49 |
| Molecular Formula: |
C25H28O3 |
| purity |
99% |
Description:
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock.
This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol.
Application:
The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical.
While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.
COA
| Product name |
Estradiol Benzoate |
| Appearance |
White crystalline powder |
| Water |
≤3.5% |
pass |
| Assay |
97 .0~ 103.0% |
99.2% |
| Loss on drying |
≤0.5% |
0.17% |
| Related substances |
total impurities ≤1.0% |
Pass |
| any individual impurity ≤0.5% |
Pass |
| Residual solvents |
ethanol ≤0.5% |
Pass |
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
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