2,2'-Dithiobis(benzothiazole) NEW

• DATA ITEMS CITED :

• 18

• MOLECULAR FORMULA :

• C14-H8-N2-S4

• MOLECULAR WEIGHT :

• 332.48

• WISWESSER LINE NOTATION :

• T56 BN DSJ CSS- CT56 BN DSJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >12 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2600 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 7 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 100 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 180 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• >7940 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 9100 mg/kg/13W-I

• TOXIC EFFECTS :

• Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 172 gm/kg/78W-I

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Parenteral

• DOSE :

• 400 mg/kg

• SEX/DURATION :

• female 4-11 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Parenteral

• DOSE :

• 400 mg/kg

• SEX/DURATION :

• female 4-11 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - fetal death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Parenteral

• DOSE :

• 800 mg/kg

• SEX/DURATION :

• male 2 day(s) pre-mating female 2 day(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Parenteral

• DOSE :

• 800 mg/kg

• SEX/DURATION :

• male 2 day(s) pre-mating female 2 day(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

• TYPE OF TEST :

• Mutation in microorganisms

• TEST SYSTEM :

• Rodent - mouse Lymphocyte

• DOSE/DURATION :

• 15 mg/L

• REFERENCE :

• ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,193,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84830 No. of Facilities: 897 (estimated) No. of Industries: 12 No. of Occupations: 28 No. of Employees: 11180 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84830 No. of Facilities: 1533 (estimated) No. of Industries: 19 No. of Occupations: 42 No. of Employees: 50590 (estimated) No. of Female Employees: 11091 (estimated)