2-Chloro-4-Methyl-6-(Methylthio)pyrimidine CAS 89466-59-1 | Core Supplier of Multifunctional Thiopyrimidine Intermediates
[Core Keywords]: 2-Chloro-4-Methyl-6-(Methylthio)pyrimidine Supplier, CAS 89466-59-1, Thiopyrimidine Agrochemical Intermediates, Pharmaceutical Building Blocks
Product Basics
Chemical Name: 2-Chloro-4-methyl-6-(methylthio)pyrimidine
CAS No.: 89466-59-1 (Title-Level Keyword Emphasis)
Molecular Formula: C₆H₇ClN₂S
Appearance: White to light-yellow crystalline solid
Purity: ≥98.5% (HPLC, industrial/pharmaceutical grade optional)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|
| Molecular Weight | 174.65 g/mol |
| Melting Point | 68-71℃ (dynamic DSC determination) |
| Boiling Point (0.5 mmHg) | 155-158℃ |
| Density (25℃) | 1.32 g/cm³ |
| Solubility | Soluble in acetone, DCM; slightly soluble in ethanol; insoluble in water |
| Flash Point (closed cup) | 110℃ |
| Storage Conditions | Light-protected, sealed, dry at room temperature |
Upstream-Downstream Industrial Chain Integration
▶ Upstream Material Guarantee
Core Intermediates: 4-Methyl-6-(methylthio)pyrimidine-2-ol, phosphorus oxychloride (POCl₃)
Process Optimization: Selective chlorination technology (yield >95%, byproducts <0.3%)
▶ Downstream Application Expansion
Agrochemical Fungicides: Molecular modification of strobilurin compounds (e.g., cyprodinil)
Antiviral Drugs: Key fragment for HCV NS5B polymerase inhibitors
Optoelectronic Materials: Organic semiconductor dopant precursor
Molecular Probes: Protein thioether bond-directed modification reagent
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|
| Agrochemicals | Broad-spectrum fungicide resistance management | Chlorine atom nucleophilic substitution activity >94% (HPLC verified) |
| Antiviral Drugs | Nucleoside analog side-chain optimization | Thioether bond oxidation stability (pH 5-9 tolerance) |
| OLED Materials | Electron transport layer hole-blocking material preparation | Purity ≥99.9% (zone melting process) |
| Chemical Biology | Targeted protein cysteine residue covalent modification | Thioether-directed coupling efficiency >92% |
SEO Keyword Matrix
Core Keyword Layout:
"2-Chloro-4-Methyl-6-(Methylthio)pyrimidine Price"
"CAS 89466-59-1 Technical Specifications"
"High-Activity Thiopyrimidine Supplier"
Long-Tail Keyword Combinations:
"Strobilurin Fungicide Intermediate Manufacturer"
"HCV Drug Pyrimidine Raw Material Supplier"
"REACH Pre-registered 89466-59-1 Producer"
Compliance Statement
✅ EINECS Status: Not listed (per ECHA database)
✅ REACH Progress: Under co-registration (SIEF member ID: CHEM-2023-XXXXX)
✅ EU Export: Supports tonnage-level formal registration (SVHC test reports available)
✅ Analysis Reports: Full documentation (HPLC, ¹H NMR, elemental analysis)
Note: Technical parameters and compliance details are subject to final verification. Contact for custom synthesis or regulatory support.
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