2-Chloro-4-(Trifluoromethyl)pyrimidine CAS 33034-67-2 | Core Supplier of High-Activity Fluoropyrimidine Intermediates
[Core Keywords]: 2-Chloro-4-(Trifluoromethyl)pyrimidine Supplier, CAS 33034-67-2, Fluoropyrimidine Agrochemical Intermediates, Antiviral Pharmaceutical Building Blocks
Product Basics
Chemical Name: 2-Chloro-4-(trifluoromethyl)pyrimidine
CAS No.: 33034-67-2 (Title-Level Keyword Emphasis)
Molecular Formula: C₅H₂ClF₃N₂
Appearance: Colorless to light-yellow transparent liquid
Purity: ≥99.0% (GC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|
| Molecular Weight | 180.53 g/mol |
| Boiling Point (5 mmHg) | 85-88℃ |
| Density (25℃) | 1.48 g/cm³ |
| Refractive Index (n²⁰/ᴰ) | 1.435-1.439 |
| Solubility | Soluble in acetone, THF; slightly soluble in ethanol; insoluble in water |
| Flash Point (closed cup) | 76℃ |
| Storage Conditions | Light-protected, sealed, 2-8℃ |
Upstream-Downstream Industrial Chain Integration
▶ Upstream Material Guarantee
Core Intermediates: 4-(Trifluoromethyl)pyrimidine-2-ol, phosphorus oxychloride (POCl₃)
Process Optimization: Low-temperature chlorination technology (selectivity >97%, byproducts <0.3%)
▶ Downstream Application Expansion
Agrochemical Fungicides: Key precursor for methoxyacrylate compounds (e.g., azoxystrobin)
Antiviral Drugs: HCV NS5A inhibitor molecular scaffold modification
Electronic Materials: Organic semiconductor dopant synthesis
Molecular Probes: Targeted protein covalent inhibitor development
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|
| Agrochemicals | Resistance-management fungicide development | Chlorine atom nucleophilic substitution activity >95% (HPLC verified) |
| Antiviral Drugs | COVID-19 main protease (3CLpro) inhibitor synthesis | Trifluoromethyl electronic effect control selectivity >93% |
| OLED Materials | Electron transport layer hole-blocking material preparation | Purity ≥99.9% (molecular distillation process) |
| Chemical Biology | Covalent inhibitor electrophile warhead design | Fluorine atom stability (pH 3-11 tolerance) |
SEO Keyword Matrix
Core Keyword Layout:
"2-Chloro-4-(Trifluoromethyl)pyrimidine Price"
"CAS 33034-67-2 Technical Specifications"
"High-Activity Fluoropyrimidine Supplier"
Long-Tail Keyword Combinations:
"Strobilurin Fungicide Intermediate Manufacturer"
"HCV NS5A Inhibitor Raw Material Supplier"
"Pharmaceutical-Grade 33034-67-2 Producer"
Compliance Statement
✅ EINECS Status: Not listed (per ECHA database)
✅ REACH Progress: PPORD exemption (R&D compliance, exemption ID: EX-2023-XXXXX)
✅ EU Export: Supports co-registration services (simplified process for annual export <1 ton)
✅ Analysis Reports: Full documentation (GC, ¹⁹F NMR, elemental analysis)
Note: Technical parameters and compliance details are subject to final verification. Contact for custom synthesis or regulatory support.
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