High Purity Anticancer API 99% CAS 13010-47-4 Lomustine
| Product Name: | Lomustine |
| Synonyms: | (chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea;(cloro-2-etil)-1-cicloesil-3-nitrosourea;1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure;1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure;belustine;nci-c04740;nsc79037;nsc-79037 |
| CAS: | 13010-47-4 |
| MF: | C9H16ClN3O2 |
| MW: | 233.7 |
| EINECS: | 235-859-2 |
| Product Categories: | Other APIs;API;Intermediates & Fine Chemicals;Nitric Ox ide Reagents;Pharmaceuticals;CEENU;Pharmaceutical |
Description:
Lomustine is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number.
Application & Function
Uses: CCNU is an oral anticancer drug that was approved by the U.S. Food and Drug Administration in 1976 for marketing, as lomustine . CCNU is used alone or in combination with other antineoplastic agents, including procarbazine and vincristine, etoposide and prednimustine, and other combinations (IARC 1981, HSDB 2009). It is used primarily in the treatment of Hodgkin's disease and brain tumors, but it has also been used to treat other cancer, includ-ing lung cancer, non-Hodgkin's lymphoma, malignant melanoma, breast cancer, kidney cancer, and cancer of the gastrointestinal tract . It has also been applied to the skin to treat mycosis fungoides and psoriasis.
Uses: Lomustine USP is used to treat Malignant brain tumors; Hodgkin's disease.
Uses :Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.
Function:
1.Lomustine is highly soluble and can be used in cerebrospinal fluid, which is often used in primary brain tumors (such as glial). Hodgkin's disease Cell tumor) and secondary tumor;
2. Treatment of solid tumors, such as combined with fluorouracil to treat gastric cancer and rectal cancer, combined with methotrexate and cyclophosphamide to treat bronchial lung cancer;
3. Treatment of Hodgkin's disease.
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