Methtestosterone properties Melting point 162-168°C(lit.) ratio of rotation 79º(C =1,alcohol) boiling point 383.47°C(roughestimate) Density 1.0434(roughestimate) Refractive index 1.4800(ESTIMATE) flash point 5°C Storage condition 2- 8°C solubility H2O:≤0.5mg/mL Photosensitive acidity coefficient (pKa)15.13±0.60(Predicted) Color White Solubility 33.88Chemicalbookmg/L(25ºC)Merck13,61 48 brn2057425inchikeygckmfjbgxuynag 58-18-4 - HLXURNFRSA - NCAS database (CASDataBaseReference) NIST chemical information 17 (Alpha) - methyl - delta4 - android Osten-17 -(Beta) -OL-3-One (58-18-4)EPA Chemical Information methyltropi (58-18-4)
Use of methyltestosterone and use of synthetic methods. Methyl testosterone mainly promotes the maturation of male reproductive organs, enables the development and maintenance of secondary sexual characteristics, and enables boars to perform male behavior. Large dose of injection, can inhibit pituitary gland secretion of gonadotropin, against estrogen. Still have the effect that promotes protein synthesis obviously, can make inside body protein decompose is reduced, increase nitrogen and inorganic salt remain inside body, make muscle developed, weight quickens. High dose can stimulate bone marrow hematopoietic function, promote erythrocyte formation. Used for the treatment of anaemia caused by sexual deficiency, trauma, fracture, aplastic or other causes in breeding boars. Usage and dosage methyl testosterone tablets, taken orally: 0.2-0.3g once a day. Chemical properties White crystalline powder, odorless, tasteless, Chemicalbook hygroscopic, photometamorphic. Mp161-166 ℃; Specific rotation [α]25D+69°-+75°(dioxane); Ethanol solution has maximum absorption at 240nm wavelength. Soluble in chloroform and dioxane, soluble in ethanol (1:5), acetone (1:10), methanol, slightly soluble in ether, difficult to dissolve in water, vegetable oil. Use in biochemical research, male hormone drugs. Use androgen drugs, used in the supplement treatment of testosterone deficiency, also can be used in the treatment of uterine bleeding, aplastic anemia and other diseases. Production method Progesterone dienolone acetate was prepared by hydroxylamine oxime, Beckman rearrangement of POCl3 and acid hydrolysis. The latter was prepared by Grignard reaction with methyl magnesium iodide and then by aluminum isopropyl alcohol oxidation.
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