99% Amitriptyline Hydrochloride/Amitriptyline HCl 549-18-8 For Antidepressants
Quick Details
Name: Amitriptyline hydrochloride
Synonyms: Amitriptyline hydrochloride; amitriptyline hcl methanol solution; AMITRYPTILLINE HCL; Amitriptyline HCl
CAS Registry number: 549-18-8
EINECS:208-964-6
Molecular Formula: C20H23NHCl
Boiling Point: 398.2 °C at 760 mmHg
Flash Point: 174 °C
Density: 1.076g/cm3
Water:slightly soluble in Water
Appearance: white to off-white powder
Usage:Antidepressant.
Safety Statements: S22;S26;S36/37/39;S45
Transport:UN 2811
Basic Information
| Product Name: | Amitriptyline hydrochloride |
| Synonyms: | 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride;Amiplin;Normaln;Amitriptyline Hydrochloride (200 mg);Methanol (test Amitriptyline HCl, 1.0 mg/mL as free base);Amitriptyline hydrochloride 98+%;Amitriptyline hydrochloride solution ;3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride |
| CAS: | 549-18-8 |
| MF: | C20H24ClN |
| MW: | 313.86 |
| EINECS: | 208-964-6 |
COA:
Items | Specification | Results |
Identification | A. Infrared absorption spectrophotometry | Conforms |
B.As obtained in the Assay | Conforms |
C. Chloride reaction | Conforms |
Inspect | Melting point | 195~199 195 to 199 | 196.5~198.0 |
Acidity | pH is 5.0 to6.0 | 5.6 |
Loss on drying | Not more than 0.5 per cent | 0.4 |
Residue on ignition | Not more than 0.1 per cent | 0.09 |
Heavy metals | Not more than 0.001 | 0.001 |
Related substances | Conforms | Conforms |
Content | 98.0 per cent to 102.0 per cent | 99.4 |
Usage:
Amitriptyline Hydrochloride is an antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
Amitriptyline is used in ankylosing spondylitis for pain relief as a preventive for patients with frequent/chronic migraines. It is also used as a preventive for patients with recurring biliary dyskinesia (sphincter of Oddi dysfunction) Amitriptyline is also used in the treatment of nocturnal enuresis in children.
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