Efavirenz

$0.00 1Kg/Bag

$0.00 25Kg/Bag

$0.00 100Kg/Bag

Min. Order0.1Kg/Bag
PurityUSP
Cas No154598-52-4
Supply Ability20 tons
Update time2024-12-20

Sinoway Industrial co., ltd.

4YR

China

Chemical Properties

Product Name	Efavirenz
CAS No	154598-52-4
EC-No	620-492-6
Min. Order	0.1Kg/Bag
Purity	USP
Supply Ability	20 tons
Release date	2024/12/20

Product Information

Product Name	Pharmaceutical Intermediate CAS 154598-52-4 Efavirenz for Anti-Allergic
Appearance	powder
cas	154598-52-4
Assay	90%
Keywords	Efavirenz; API Efavirenz powder;Efavirenz Medicine
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

Usage

What is Efavirenz ?

Efavirenz D5 (Sustiva)84 is also mandated for use with at leasttwo other antiretroviral agents. The compound is morethan 99% protein bound, and CSF concentrations exceedthe free fraction in the serum. Metabolism occurs in theliver. The half-life of a single dose of Efavirenz D5 is 52 to 76hours, and 40 to 55 after multiple doses (the drug inducesits own metabolism). Peak concentration is achieved in 3to 8 hours. Elimination is 14% to 34% in urine (as metabolites)and 16% to 41% in feces (primarily as Efavirenz D5).The oral dosage form is supplied as a capsule.

Function of Efavirenz

Efavirenz is one of the most commonly prescribed antiretroviral medications in the world. Several large randomized, controlled trials[RCTs] have demonstrated the superior ability of efavirenz to suppress the HIV virus when used as part of a 3-drug cocktail[2]. The introduction of Atripla in 2006 combined efavirenz and two other agents into a single pill, once-daily formulation. This formulation was more convenient and better tolerated than alternatives, and thus resulted in improved adherence to antiretroviral medications[3]. However, neuropsychiatric side effects associated with efavirenz have been reported to occur in 40-50% of patients and represent one of the limiting factors of this regime

Application of Efavirenz

For use in combination treatment of HIV infection (AIDS)

COA

Test items	Specification
Appearance	White to off-white crystalline powder
solubility	50mg/ml in Methanol Solvent,clear
Water	≤0.5%
Related substance	Impurity A ≤0.15%
	Impurity B ≤0.40%
	Impurity C ≤0.10%
	Impurity D ≤0.10%
	Impurity E ≤0.10%
	Impurity I ≤0.25%
	Impurity K ≤0.10%
	Other unknown individual impurity ≤0.10%
	Total impurities ≤0.10%
Isomeride	≤0.5%
Heavy Metal	≤20ppm
Residue on ignition	≤0.2%
Assay	Not less than 98%