Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. It may also be used to control juvenile rheumatoid arthritis. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
| Melting point | 195°C |
| Boiling point | 561.26°C (rough estimate) |
| alpha | +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis) |
| density | 1.4080 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| Fp | 11℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: insoluble |
| form | powder |
| pka | pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain) |
| color | Light yellow to yellow |
| Water Solubility | Insoluble. <0.1 g/100 mL at 19 ºC |
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