Methotrexate

CAS:

59-05-2

MF:

C20H22N8O5

MW:

454.45

EINECS:

200-413-8

MDL No.:

MFCD00064370

Melting point:

195°C

alpha 

+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)

Boiling point:

561.26°C (rough estimate)

Density 

1.4080 (rough estimate)

refractive index 

1.6910 (estimate)

Flash point:

11℃

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

H₂O: insoluble

pka

pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

form 

powder

Water Solubility 

Insoluble. <0.1 g/100 mL at 19 ºC

Sensitive 

Light Sensitive & Hygroscopic

Merck 

14,5985

BRN 

70669

Stability:

Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.

InChIKey

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Symbol(GHS) 

GHS06,GHS08

Signal word 

Danger

Hazard statements 

H301-H315-H319-H341-H360D

Precautionary statements 

P201-P301+P310+P330-P302+P352-P305+P351+P338

Hazard Codes 

T,F

Risk Statements 

61-25-36/38-46-39/23/24/25-23/24/25-11

Safety Statements 

53-26-36/37-45-36/37/39-36-16

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

MA1225000

F 

3-8-10

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29335995

Toxicity

LD50 oral in rat: 135mg/kg