Introduction
| Product name: | Afatinib (BIBW 2992);Gilotrif |
| Synonyms: | BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide |
| CAS: | 439081-18-2 |
| MF: | C24H25ClFN5O3 |
| MW: | 485.944 |
| Purity: | 99.5% min |
| Appearance: | White or Nearly White Crystalline Powder |
| MOQ: | 10G |
| Specifications: | Pharmaceutical Grade |
| Deliver time: | About 5 days |
| Deliver methods: | TNT,EMS,HKEMS,DHL,ect.(door to door) |
Afatinib is pronounced aff-a-tin-ib. It has the brand name Giotrif (jee-oh-triff). It is a type of biological therapy called a tyrosine kinase inhibitor (TKI). It is a treatment for non small cell lung cancer that has spread outside the lung or to other parts of the body.
It has received regulatory approval for use as a treatment for non-small cell lung cancer,although there is emerging evidence to support its use in other cancers such as breast cancer.
3. How afatinib works:
This type of drug works by blocking particular proteins on cancer cells that encourage the cancer to grow. Afatinib blocks proteins called epidermal growth factor receptors (EGFR). Cancers that have these receptors are called EGFR positive.
Between 10 and 15 people out of every 100 with non small cell lung cancer (10 to 15%) have EGFR positive cancer. Doctors check your cancer cells to see if they have the receptors before you have this treatment.
Afatinib may shrink the cancer or stop it growing for a time
4. Uses and fuction:
Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells. It binds to a certain protein (epidermal growth factor receptor-EGFR) in some tumors.
5. Mechanism of action:
Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation tyrosine-kinase inhibitors (TKIs) likeerlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
COA:
| Item | Requirements | Test Results |
| Description | Off-white powder | Off-white powder |
| Identification | HPLC ,NMR | Complies |
| Residue on Ignition | ≤0.10% | 0.05% |
| Loss on Drying | ≤0.50% | 0.15% |
| Heavy Metal | ≤20ppm | <20ppm |
| Purity(HPLC) | ≥99.0% | 99.99% |
| Conclusion | It complies with EnterpriseStandard |
About Us
Our company is a hi-tech enterprise integrating R & D, production, agency and sales of fine chemicals such as inorganic chemicals, organic chemicals, flavors and fragrances, pharmaceutical raw materials and intermediates. We have established long-term cooperation with many large group companies at home and abroad.
FAQ:
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal and so on.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
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