Chemical Name:Memantine hydrochloride
CAS No :41100-52-1
Molecular Weight:215.76
Properties:white crystalline powder.
melting point: 290-295deg C.
Specification: ≥98.5%(GC)
Packing:25kg/bag,Composite woven bag(plastic bag inside)or PE bag, or 25kg/carton.
Storage&Transportation:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from
incompatible substances. Avoid to contact water or moisture during storage&transportation.
Usage:
Used in field of medicines,to make Memantine Hydrochloride Tablet,which treat dementia of the alzheimer type etc.
Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European. The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other.
Item | Specification | Result |
Appearance | White crystalline power | Conforms |
Loss on drying | ≤1.0% | 0.31% |
PH | 4.5~6.5 | 5.2 |
Residue on ignition | ≤0.1% | 0.04% |
Assay | 98.0-102.0% | 99.86% |
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