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ChemicalBook Product Catalog Natural Products Phenols PICEATANNOL

1/2

PICEATANNOL NEW

$1.00 100KG

$5.00 25KG

$6.00 1KG

Min. Order1KG
Purity99%
Cas No10083-24-6
Supply Abilityg-kg-tons, free sample is available
Update time2024-03-29

Henan Fengda Chemical Co., Ltd

1YR

China

Since2023-02-10

AddressRoom 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Chemical Properties

Product Name	PICEATANNOL
CAS No	10083-24-6
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/03/29

1. Product information

Names

Name	Piceatannol
Synonym	More Synonyms

Piceatannol Biological Activity

Description	Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer Natural Products >> Phenols
References	[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Description

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk

Research Areas >> Cancer

Natural Products >> Phenols

References

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.

[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	507.3±38.0 °C at 760 mmHg
Melting Point	223-227ºC
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.243
Flash Point	252.2±21.4 °C
Exact Mass	244.073563
PSA	80.92000
LogP	2.69
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.801
Storage condition	2-8°C
Water Solubility	H2O: 0.5 mg/mL

MSDS

Piceatannol MSDS(Chinese)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2907299090

Customs

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles92

A unique mechanism of curcumin inhibition on F1 ATPase

Biochem. Biophys. Res. Commun. 452(4) , 940-4, (2014)

• Polyphenols lowered the rotation rate of F1 ATPase by increasing catalytic dwell. • Curcumin showed different inhibitory mechanism from other polyphenols. • γ subunit carboxyl terminus is not requir...

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

J. Immunol. 194(4) , 1856-66, (2015)

During secondary immune responses, Ab-opsonized bacteria are efficiently taken up via FcRs by dendritic cells. We now demonstrate that this process induces cross-talk between FcRs and TLRs, which resu...

TH2 cells and their cytokines regulate formation and function of lymphatic vessels.

Nat. Commun. 6 , 6196, (2015)

Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the r...

Synonyms

3,3',4'5-Tetrahydroxystilbene

E-Piceatannol

1,2-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-

3,3′,4,5′-Tetrahydroxy-trans-stilbene

3,3',4,5'-Tetrahydroxy-trans-stilbene

3,4,3',5'-Tetrahydroxy-trans-stilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol

3,5,3',4'-tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol

Piceatannol

4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol

MFCD00221715

4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol

(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol

trans-3,3',4,5'-tetrahydroxystilbene

3,3',4,5'-tetrahydroxystilbene

Piceatannol, (E)-

Safety Information

Synthetic Route

Total: 1 Page

Customs

Synonyms

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping

4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137

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Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.