Benzamide, N-(2-fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

Flufenoxadiazam is a fungicide. Flufenoxadiazam has potent fungicidal activity, particularly against Phakopsora pachyrhizi and Puccinia triticina[1].

Flufenoxadiazam is produced through a multi-stage industrial route that typically begins with preparation of the appropriately functionalised precursor, often a substituted aniline, phenoxy, or heteroaryl unit, followed by controlled cyclisation steps that generate the oxadiazole or related diazam ring system under conditions that prevent over reaction or decomposition. Once the heterocycle is established, the key coupling step links it with the fluorinated aromatic or heteroaromatic moiety, using reagent and solvent choices that protect the sensitive nitrogen-oxygen framework.

Succinate DeHydrogenase Inhibitor

[1] Zhong L, et al. 1,2,4-Oxadiazole as a potential scaffold in agrochemistry: a review. Org Biomol Chem. 2023 Sep 27;21(37):7511-7524. DOI:10.1039/d3ob00934c

Fungicide