ChemicalBook Product Catalog Biochemical Engineering Plant extracts Animal Extracts SARAFOTOXIN S6C

SARAFOTOXIN S6C

Product NameSARAFOTOXIN S6C
CAS121695-87-2
MFC103H147N27O37S5
MW2515.75
EINECS
MOL File121695-87-2.mol

Chemical Properties

storage temp.	-20°C
solubility	DMSO: Sparingly Soluble: 1-10 mg/ml
form	solid
color	white
Water Solubility	Soluble to 1 mg/ml in water
InChIKey	LXPHPKVWHQLBBA-UHFFFAOYSA-N

Safety Information

WGK Germany	3
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 1 Inhalation Acute Tox. 1 Oral

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Biochem/physiol Actions

Sarafotoxin S6c is an endothelin ETB agonist. It is a peptide isotoxin with strong vasoconstrictor activity, obtained from the Middle Eastern snake, Atractaspis engaddensi. The toxin is composed of 21 amino acids.

in vivo

Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels^[1].

Animal Model:	Male Wister rats, exposed to 10% O₂ [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks^[1]
Dosage:	1 pM-1 mM
Administration:
Result:	Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

storage

-20°C

References

[1] MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. DOI:10.1097/00005344-199511000-00020
[2] CHIKAHISA TAKASAKI . Sarafotoxins S6: Several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart[J]. Toxicon, 1988, 26 6: Pages 543-548. DOI: 10.1016/0041-0101(88)90234-6
[3] DAVID L. WILLIAMS JR. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes[J]. Biochemical and biophysical research communications, 1991, 175 2: Pages 556-561. DOI: 10.1016/0006-291x(91)91601-8
[4] J. BALWIERCZAK. Characterization of a Potent and Selective Endothelin‐B Receptor Antagonist, IRL 2500[J]. Journal of Cardiovascular Pharmacology, 1995, 26 1: S393-396. DOI: 10.1097/00005344-199506263-00116

SARAFOTOXIN S6C Supplier

Related Product Information

Send Inquriy