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Phenyl carbamate

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Phenyl carbamate Basic information
Phenyl carbamate Chemical Properties
  • Melting point:149-152 °C(lit.)
  • Boiling point:251.96°C (rough estimate)
  • Density 1.2528 (rough estimate)
  • refractive index 1.5030 (estimate)
  • pka12.33±0.50(Predicted)
  • Water Solubility Soluble in water.
  • BRN 2042627
  • CAS DataBase Reference622-46-8(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • HS Code 29242998
Phenyl carbamate Usage And Synthesis
  • Chemical Propertieswhite to very slightly pink crystalline flakes
  • UsesPhenyl carbamate is used as various phenyl carbamate esters derived from amino acids, a dipeptide and amino acid esters and amides were prepared and assessed as potential prodrugs with the aim of protecting phenolic drugs against first-pass metabolism following per oral administration.

    A tin-catalyzed transcarbamoylation of primary and secondary alcohols with phenyl carbamate proceeds smoothly in toluene at 90℃ to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.
    Y. Ichikawa, Y. Morishita, S. Kusaba, N. Sakiyama, Y. Matsuda, K. Nakano, H. Kotsuki, Synlett, 2010, 1815-1818.
Phenyl carbamate Preparation Products And Raw materials
Phenyl carbamate(622-46-8)Related Product Information
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