ANTI-CHOLINE ACETYLTRANSFERASE

Anti-Choline Acetyltransferase- Goat Polyclonal Antibody

Goat

Human, Mouse, Rat, Guinea Pig, Chicken, and Non-Human Primates

Unconjugated WB, IHC

SignalChem

Western blot of rat brain lysate showing specific immunolabeling of the ~70k Choline Acetyltransferase.

Choline acetyltransferase (ChAT )is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (2). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (1). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (3).

ANTI-CHOLINE ACETYLTRANSFERASE是ANTI-CHOLINE ACETYLTRANSFERASE为抗原制得的免疫抗体，可以特异性结合CHOLINE ACETYLTRANSFERASE。主要用于检测CHOLINE ACETYLTRANSFERASE的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。