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Monensin

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Monensin Basic information
Monensin Chemical Properties
  • Melting point:103-105°C
  • alpha D +47.7°
  • Boiling point:608.24°C (rough estimate)
  • Density 1.0773 (rough estimate)
  • refractive index 1.5465 (estimate)
  • storage temp. 2-8°C
  • pka6.6 (in 66% DMF)
  • CAS DataBase Reference17090-79-8(CAS DataBase Reference)
  • EPA Substance Registry SystemMonensin (17090-79-8)
Safety Information
  • Hazard Codes T
  • Risk Statements 25
  • Safety Statements 36/37/39-45
  • RIDADR UN 3462 6.1/PG 2
  • WGK Germany 3
  • RTECS JH2830000
  • HazardClass 6.1(a)
  • PackingGroup II
  • Hazardous Substances Data17090-79-8(Hazardous Substances Data)
  • ToxicityLD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn)
MSDS
Monensin Usage And Synthesis
  • Chemical PropertiesCrystallin Solid
  • UsesMonensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.
  • UsesPoliether antibiotic. Coccidiostat
  • UsesMonensin (2) C36H62O11, a carboxylic acid which is used as its water-soluble sodium salt (Coban, Rumensin). Monensin is also used to treat histomoniasis. The polyether ionophoric antibiotics are capable of complexing and interfacing with specific alkali metal cations to render them lipid-soluble and diffusible across parasite mitochondrial membranes. Related useful polyether antibiotics are narasin and lasalocid (3, Lasalocid A, C34H54O8,).
  • brand nameCoban [as sodium salt] (Lilly);Rumensin [as sodium salt] (Lilly).
  • Safety ProfilePoison by ingestion and intraperitoneal routes. An eye and skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Monensin(17090-79-8)Related Product Information
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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