1-Bromo-2,4,5-trifluorobenzene

367-23-7

327-52-6

The general procedure for the synthesis of 2,4,5-trifluorobromobenzene from 1,2,4-trifluorobenzene was as follows: 100 g of 1,2,4-trifluorobenzene and 3 g of tin tetrachloride-polystyrene complex were added to a 500 mL three-necked flask, and glacial acetic acid was used as the reaction solvent. At room temperature, 127 mL of liquid bromine was added slowly and dropwise. The reaction lasted for 2 h, during which the progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that the ingredients were fully reacted, vacuum evaporation was performed to remove the glacial acetic acid. Subsequently, 500 mL of chloroform was added and the organic phase was washed with 3% dilute hydrochloric acid, followed by the addition of saturated sodium sulfite solution to remove residual bromine from the organic phase. After sequential washing, the organic phase was washed with saturated saline. Finally, the solvent was removed by distillation to afford 158 g of 2,4,5-trifluorobromobenzene in 98.7% yield and 99.6% purity as shown by gas chromatography analysis.