Tetrahydrofuran-d8

colourless liquid with an ether-like odour

Tetrahydrofuran-d_8 is a deuterated THF that is used in various synthesis reactions and also used as a precursor for various polymers.

ChEBI: Oxolane-d8 is a deuterated compound, a cyclic ether, a member of oxolanes, a saturated organic heteromonocyclic parent and a volatile organic compound.

Tetrahydrofuran-d₈ may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.

Tetrahydrofuran-d8 was prepared from the exchange of tetrahydrofuran with heavy water catalyzed by a transition metal: a CD3OD mixture of tetrahydrofuran (0.22 mmol) and pyrene-imidazolylidene-iridium(III) complex (2 mol% based on the metal) was heated in a Schlenk tube equipped with a Teflon cap at 100C. AgOTf (8.8 10-3 mmol) was added to the solution. After 12 h, a 50-L aliquot was withdrawn from the reaction vessel. An aliquot was added to an NMR tube containing 0.6 mL of CDCl3. Highly substituted tetrahydrofuran-d8 was obtained using a standard capillary consisting of a solution of ferrocene in CDCl3 (0.025 mg L-1) and the deuteration level was monitored by 1H NMR.