Methanol-d4

colourless liquid

Methanol-d4 has a slightly higher density than methanol because deuterium atoms are heavier than hydrogen atoms. It exhibits distinct characteristics in its nuclear magnetic resonance (NMR) spectrum, with characteristic deuterium signals arising from the nuclear spin of deuterium.

Methanol-d4 may be used as a solvent to analyze the rate of exchange of methoxyl group in camphor and norcamphor dimethyl ketals.

Methyl Alcohol-d4 is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR).

ChEBI: Methanol-d4 is a deuterated compound that is methanol in which all four hydrogen atoms are replaced by deuterium. It is commonly used as a solvent in NMR spectroscopy. It has a role as an amphiprotic solvent.

Methanol-d₄ (CD₃OD) is a deuterated NMR solvent used for NMR-based research and analyses. It has the highest isotopic enrichment and will not interfere with the desired level of detection.
The absolute infrared absorption intensities of CD3OD have been reported between 8000 and 350cm^-1.

A preparation method for providing per-deuterated methanol is provided, specifically: opening the valve of deuterium gas and carbon monoxide, and controlling the volume ratio to be 1:1 to carry out premixing (deuterium gas and carbon monoxide are respectively 2kg and 14kg, a total of 16kg). Under the pressure of 5.5MPa, at a speed of 2L/s, through the catalyst bed layer of gold oxide: platinum oxide: rhodium oxide = 1:3:2 (mass ratio) at 210~380℃, after continuous circulation reaction for 24 hours, in The per-deuterated methanol reaction solution was obtained from the separation kettle, and the obtained reaction solution was rectified to give Methanol-d4: 3.2 kg, yield 35.5%, purity 99.8%.