Histone H3K27Me1 (15-39)-K-biotin (trifluoroacetate salt)

Histone H3K27Me1 (15-39) is a peptide fragment of histone H3 that corresponds to amino acid residues 16-40 of the human histone H3.1 and H3.2 sequences. It is monomethylated at lysine 27 and biotinylated via a C-terminal lysine linker. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation.1 Levels of H3K27Me1 are increased in patients with metastatic hormone-naïve and castration-resistant prostate cancer.2WARNING This product is not for human or veterinary use.

[1] KARIN J FERRARI. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.[J]. Molecular Cell, 2014, 53 1: 49-62. DOI: 10.1016/j.molcel.2013.10.030
[2] JÖRG ELLINGER. Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.[J]. Cancer Investigation, 2012, 30 2: 92-97. DOI: 10.3109/07357907.2011.636117