(D-Ala2)-leucine enkephalin-Arg

Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].

δ Opioid Receptor/DOR

[1] Titov MI, et al. Dalargin--a peptidny preparat s tsitoprotektivnym destviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):72-6. PMID:2998416
[2] Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220(3):303-8. DOI:10.1016/j.toxlet.2013.04.023
[3] Polonski VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo destviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'no modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103(4):433-4. PMID:3032303