醉茄素 A
醉茄素 A 性质
| 熔点 | 252-253℃ |
|---|---|
| 比旋光度 | D28 +125° (c = 1.30 in CHCl3) |
| 沸点 | 680.7±55.0 °C(Predicted) |
| 密度 | 1.28 |
| 闪点 | 226℃ |
| 储存条件 | Desiccate at -20°C |
| 溶解度 | 可溶于 DMSO（高达 20 mg/ml） |
| 酸度系数(pKa) | 13.49±0.70(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色 |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
醉茄素 A 用途与合成方法
| Target | Value |
|
NF-κB
() | |
|
vimentin
() |
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.
醉茄素 A 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | S8587 | 醉茄素 A | 5119-48-2 | 1mg | 1470.11 |
| 2024-11-08 | S8587 | 醉茄素 A | 5119-48-2 | 5mg | 4290.34 |
