RG-13022
RG-13022 性质
| 熔点 | 116.0 to 120.0 °C |
|---|---|
| 沸点 | 423.8±45.0 °C(Predicted) |
| 密度 | 1.172±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 可溶于DMSO或乙醇：可溶 |
| 酸度系数(pKa) | 3.03±0.12(Predicted) |
| 形态 | 白色固体。 |
| 颜色 | 白色到黄色到绿色 |
| InChI | 1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3 |
| InChIKey | DBGZNJVTHYFQJI-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2 |
RG-13022 用途与合成方法
| Target | Value |
|
EGFR
(Cell-free assay) | 4 μM |
RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC 50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC 50 s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action.
RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice.
RG-13022 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-101429 | RG-13022 | 136831-48-6 | 2mg | 400 |
| 2026-09-15 | HY-101429 | RG-13022 | 136831-48-6 | 5mg | 560 |
