white to light cream powder
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
ChEBI: Doxylamine succinate is an organic molecular entity.
Decapryn (Sanofi Aventis); Unisom (Pfizer).
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
