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Basic information Description References Safety Related Supplier
cis-1,2-Diaminocyclohexane Basic information
cis-1,2-Diaminocyclohexane Chemical Properties
  • Melting point:8°C
  • Boiling point:92-93 °C/18 mmHg (lit.)
  • Density 0.952 g/mL at 25 °C (lit.)
  • vapor pressure 0.4 mm Hg ( 20 °C)
  • refractive index n20/D 1.493(lit.)
  • Flash point:161 °F
  • pka9.93(at 20℃)
  • form Low Melting Solid
  • color Brown
  • CAS DataBase Reference1436-59-5(CAS DataBase Reference)
  • NIST Chemistry Referencecis-1,2-Cyclohexanediamine(1436-59-5)
Safety Information
  • Hazard Codes C
  • Risk Statements 34
  • Safety Statements 26-36/37/39-45
  • RIDADR UN 2735 8/PG 2
  • WGK Germany 3
  • 10-34
  • HazardClass 8
  • PackingGroup II
  • HS Code 29213000
cis-1,2-Diaminocyclohexane Usage And Synthesis
  • Descriptioncis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor. 
  • ReferencesKhokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
    Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
    Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
    Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
  • Chemical PropertiesClear colorless liquid
  • Purification MethodsDry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.]
cis-1,2-Diaminocyclohexane Preparation Products And Raw materials
cis-1,2-Diaminocyclohexane(1436-59-5)Related Product Information
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